For the long story on mitochondria see: http://en.wikipedia.org/wiki/Mitochondria In the short term we are concerned with our energy factories numbering anywhere from 200 to 2,000 per everyone of your approximately one hundred trillion cells, you didn’t know?

 Even as a scientist one finds it somewhat difficult to even imagine a production unit so infinitely small. But they are there, and take up about 80% of the oxygen we breath and importantly rely on up to 90 nutrients to produce our energy .

 And how is that achieved? The food we eat is oxidized to produce high-energy electrons that are converted to stored energy. This energy is stored in high energy phosphate bonds in a molecule called adenosine triphosphate, or ATP. ATP is converted from adenosine diphosphate by adding the phosphate group with the high-energy bond. Various reactions in the cell can either use energy (whereby the ATP is converted back to ADP, releasing the high energy bond) or produce it (whereby the ATP is produced from ADP). So there you have it but apologies for the gobbledygook, there is no easier way and in our case does not matter. What matters is: ATP production in the mitochondria generates free radicals which can cause localised oxidative stress and damage the mitochondria. By the way your mitochondrion have their very own DNA.

 But first, one-up for the femmes: In mammals, 99.99% of mitochondrial DNA (mtDNA) is inherited from the mother.  This is because the sperm carries its mitochondria around a portion of its tail and has only about 100 mitochondria compared to 100,000 in the oocyte. As the cells develop, more and more of the mtDNA from males is diluted out.  Hence less than one part in 10⁴ or 0.01% of the mtDNA is paternal.  This means that mutations of mtDNA can be passed from mother to child.  Congratulations ladies! But then you always knew your superiority ladies didnya?

 The mitochondria are the only place in the cell where oxygen can be combined with the food molecules. After the oxygen is added, the material can be digested. They are working organelles that keep the cell full of energy. A mitochondrion may also be involved in controlling the concentration of calcium (Ca) within the cell. 

 Antioxidants protect the mitochondria against oxidative stress by acting as free radical scavengers and are therefore vital for all energy-dependant processes, including heart muscle contraction. Supplementing with specific nutrients may help build up the body’s energy reserves and may improve stamina and endurance.

The heart is the most susceptible of all the organs to premature ageing and oxidative stress; free radical induced damage is believed to contribute to cardiovascular disease through a number of pathways.

Damage - and subsequent dysfunction – through a wide variety of determinants in mitochondria is an important factor in a wide range of human diseases. Mitochondrial disorders often present as neurological disorders, but can manifest as myopathy, (muscle disorders) diabetes, multiple endocrinopathy, (all or any of your glands) or a variety of other systemic manifestations, and very importantly all autoimmune diseases.

 Environmental influences may also interact with hereditary predispositions and cause mitochondrial disease. For example, there may be a link between pesticide exposure and the later onset of Parkinson's disease.

Other pathologies with aetiology involving mitochondrial dysfunction include schizophrenia, bipolar disorder, dementia, Alzheimer's disease, Parkinson's disease, epilepsy, stroke, cardiovascular disease, retinitis pigmentosa (eyes), and diabetes mellitus.

Mitochondria are sometimes said to have their own genome, often referred to as the "mitochondrial genome". Back to wikepedia for that one, but suffice to say the genome stored in the mitochondrial DNA if likened to a book would be about one billion words long, fascinating ain’t  it? We are going to talk more on genomes and food as “Nutrigenomics” soon.

Aging

Do not be confused here by my terminology 'healthy aging" being confined to older people.

You began to age from conception!

 Thus, my work begins with the new born and gravitates through the life stages to finality.

Those of you born since about 1950 were compromised in health status from day one by numerous factors both biological and societal, including of course a major player known as “Dr. Spock", who  in the fifties said  of the children "let them do what they like, and they will work it out", or words to that effect.

 One wrote a paper in 1982 that the "baby boomers" would eventually break the bank, meaning the Federal government "medibank". Time moves on, we now have the baby boomers children and more than a few of their children.

 And believe me, if you will; "they are breaking the bank". Whilst governments, owned mostly by BIG PHARMA ably abetted by the medical profession, both vested interests in keeping you sick, waffle on month in month out, year by year, ad infinitum, about fixing it all. This one calls "bully Poop". And about as effective in health care.

 Apologies for the typographical error! It cannot possibly be "health care" can it? Because if you were healthy, you would not need doctors, or medicine. No, this is a "wish" nomenclature and if the nomenclature is wrong you may bet your "sweet bippy" whatever that is, that the action will also be wrong! So I call it "sick care".

 Allow now a little digression, I do it all the time, as any one of my past twenty odd thousand patients will attest. In this "lucky country" an irrefutable truism today we have a National Health Summary 2004, which shows more than 70% of the population suffering one or more chronic illness conditions. Our first summary (1947) showed only 42%. End of summaries!

 One has conducted epidemiological surveys for the past twenty five years on the 14 to 25 year age group who in 1985 showed 66% for chronic illness and in 2004 70% or more.

 Interestingly one recently obtained copy (PDF 132 pages) of a Federal Department of Health & Aging nutrition survey 1983/85 to 1995. Rather enlightening even to a mathematical drop out like me self.

 I certainly would appreciate input on some results to be shared soon.

 My quandary includes the irrefutable facts that whilst intake of cereal grains, fruit and vegetables increased, whereas intake of fats and cholesterol fell the Basal Metabolic Index (BMI) rose significantly as did according to other data cardiovascular disease, cerebrovascular disease, diabetes and most other disease and chronic illness conditions?

 HMG that's a spiritual saying! They knew all of this in 1995 and yet (maybe I am dumb) we achieved that highly prized, at least by BIG PHARMA, award: The Fattest Nation on Earth.

 Mind you I knew they could do it!

 My BMI? 23.

 What's yours?

 It's all about the mitochondria!